Meet the NOTOX project @ EUROTOX 2015

The NOTOX research consortium, headed by Prof. Dr. Elmar Heinzle of Saarland University and supported by the management and dissemination partner Eurice, is pleased to share with you exciting outcomes of its ambitious project at the occasion of its symposium Predicting Long Term Toxic Effects Using Computer Models Based on Systems Characterization of Organotypic Cultures – The NOTOX Project taking place during the EUROTOX 2015 in Porto.

NOTOX is one of the building block projects of the European research initiative ‘Safety Evaluation Ultimately Replacing Animal Testing’ (SEURAT) funded by the EU-FP7 HEALTH programme and the European Cosmetics Association, Cosmetics Europe.

The overall aim of NOTOX is to develop an integrated multifaceted experimental and computational platform by applying a systems biology approach for long-term toxicity prediction on molecular, cellular and tissue level. The experimental work is focused on the application of cellular systems that come closest to human in vivo situation and their transfer into applicable and easy-to-handle test systems. In these test systems viability and physiological toxicity response parameters, “-omics”, are monitored together with genetic, epigenetic and structural characteristics. Eventually, multi-scale models of regulatory and metabolic pathways as well as cellular systems together with bioinformatics integration of human and cross species literature data are used for reliable toxicity prediction.

Symposium: Predicting Long Term Toxic Effects Using Computer Models Based on Systems Characterization of Organotypic Cultures – The NOTOX Project

Date: September 14, 2015

Time: 1.30 – 3.30 p.m.

Room: Infante Hall

Venue: Alfândega Congress Centre Porto, Portugal

Preliminary programme:

Welcome and introduction
Elmar Heinzle, Saarland University, Saarbruecken, Germany

Improved in vitro systems for prediction of hepatotoxicity
Magnus Ingelman-Sundberg, Karolinska Institutet, Stockholm, Sweden

Toxicoproteomics applied to in vitro investigation of liver toxicity using HepaRG cells
Fabrice Bertile, CNRS, Strasbourg, France

Model and in vitro based prediction of human hepatotoxicity
Jan G. Hengstler, IfADo, Dortmund, Germany

Prediction of long term toxic effects by genome based network models
Lothar Terfloth, Insilico Biotechnology AG, Stuttgart, Germany

Final remarks and closure
Fozia Noor, Saarland University, Saarbruecken, Germany

We are looking forward to meeting you in Porto!

Please register @ www.eurotox2015.com

Your Contact
Dr Verena Peuser
European Research and Project Office GmbH
Tel.: +49 30374415832
Email