METASTRA

METASTRA aims to transform the way clinicians assess fracture risk in cancer patients with vertebral metastases. METASTRA will develop innovative artificial intelligence and Physiology-based (VPH) mechanical computational models to accurately stratify patients with spine metastasis who are at high risk of fractures and identify personalised surgical treatments. The project will integrate the computational models into a user-friendly Decision Support System (DSS) tailored to meet regulatory requirements and future commercialisation opportunities. METASTRA’s innovative guidelines for patient stratification and management are expected to significantly reduce uncertain diagnoses from the current 60% to a mere 20% of cases, potentially saving up to 2.4 billion euros annually in healthcare expenditures.