SINPAIN

Osteoarthritis is the most common chronic joint disorder worldwide, but there is no efficient treatment so far. Therefore, new medications are needed to improve the quality of life for those affected and reduce the high costs associated with this disease. Taking advantage of the explosion of RNA technologies in the last years, the SINPAIN project sets out to fill this gap by developing a safe, efficient and cost-effective small interfering RNA (siRNA)-based therapy combining RNA technology with improved intraarticular hyaluronic acid-based knee viscosupplement (IA-HA) containing tissue engineering tools, such as nanocarriers. Ultimately, the team aims to develop more personalised diagnostic and treatment options for different stages of osteoarthritis.