Yeast cell factory for mRNA bioproduction
Messenger RNA (mRNA) vaccines have become a game-changer in the fight against COVID-19. Currently, in vitro transcription (IVT) is the only available technology for mRNA production; however, it relies on a complex supply chain and a costly purification process. Yscript’s groundbreaking nature lies in the generation of a specific mRNA bioproduction process in yeast, integrating innovative extraction and purification processes, representing a complete shift of paradigm compared to IVT production and a revolutionary new use of yeast. The project will significantly advance the current state of the art of mRNA manufacturing, which will foster citizens’ well-being and health while decreasing economic and social disparities associated with biopharmaceutical-based therapies.
- Professor Chantal PichonCNRSEmail